NOFO: Global Implementation Science for Equitable Cancer Control

Grant Size $500,000 to $1 million   ,   Closing Date


The Department of Health and Human Services is seeking applications for Global Implementation Science for Equitable (GlobalISE) Cancer Control to build a consortium of implementation science centers in low- and middle-income countries (LMICs).

This initiative will support implementation science research capacity-building activities, including research projects that identify, develop, and test innovative theory-based strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based cancer control interventions (e.g., programs, tools, policies, and guidelines) in LMICs.

This initiative aims to foster LMIC-based implementation science programs to inform implementation of cancer control efforts in LMICs.

  • This FOA supports efforts to conduct and build capacity for global implementation science for cancer control in LMICs through U54 research centers. Each Center will identify an overall scientific theme and specific goals. Potential theme areas for a Center to focus on include but are not limited to:

    • Advancing understanding of intervention adaptation in the context of clinical and community settings;

    • Developing and testing implementation strategies to efficiently bundle cancer control services (e.g., multiple cancer control intervention);

    • Developing and testing implementation strategies to effectively integrate cancer control into primary care or other care settings;

    • Developing and testing implementation strategies to decentralize cancer control services to community settings;

    • Developing and testing strategies to enhance patient retention across the continuum of cancer care in fragmented systems;

    • Advancing understanding around sustainment of evidence-based cancer control interventions;

    • Advancing understanding around scaling up evidence-based cancer control interventions across systems and communities.

  • The Center and its components should be integrated and connected by one overarching theme. Center applicants must be from, or partner with, an LMIC-based institution. The proposed U54 Center must include all the required components listed:

    • Research Projects. At least two, but not exceeding three, well-defined research projects are required. Each project must address a question that advances scientific knowledge in cancer control implementation science in LMICs and at least one project must test an implementation strategy. The proposed projects must be well developed, rigorous, and supported by a strong rationale that is based on integrating the available relevant information from various sources (e.g., extant literature).

    • Administrative and Engagement Core will be responsible for the overall administration, coordination, and management of the Center. The Core will also be critical in fostering productive collaboration between researchers and key stakeholders in the LMIC setting (including practitioners and health system leaders) throughout all phases of the award. Partnership and dissemination activities may include the presentation of findings from research projects and pilot projects to translate findings into sustainable community and system-level changes at the local level and beyond. Core activities are expected to contribute to scientific advancements such as improved implementation of interventions based on local knowledge and strengthened practitioner-engaged research approaches.

    • Research Capacity Building Core will focus on activities to facilitate and enhance the professional development of early-career LMIC-based investigators to build a cadre of scholars who are well versed in conducting implementation science in LMICs. Further, this core will identify and incorporate into all the research and pilot projects the use of implementation science frameworks, designs, and contextual, process, and outcome measures, accounting for multiple socioecological levels, and if relevant, include details on the development and use of emerging and innovative technologies relevant to the research.

Funding Information
  • Award Budget: Application budgets need to reflect the actual needs of the proposed project but must not exceed $750,000 per year in direct costs.

  • Award Project Period: Project period of 5 years is required.

Eligibility Criteria
  • Eligible Organizations: Higher Education Institutions

    • Public/State Controlled Institutions of Higher Education

    • Private Institutions of Higher Education

    • The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

      • Hispanic-serving Institutions

      • Historically Black Colleges and Universities (HBCUs)

      • Tribally Controlled Colleges and Universities (TCCUs)

      • Alaska Native and Native Hawaiian Serving Institutions

      • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

    • Nonprofits Other Than Institutions of Higher Education

      • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)

      • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

    • For-Profit Organizations

      • Small Businesses

      • For-Profit Organizations (Other than Small Businesses)

    • Local Governments

      • State Governments

      • County Governments

      • City or Township Governments

      • Special District Governments

      • Indian/Native American Tribal Governments (Federally Recognized)

      • Indian/Native American Tribal Governments (Other than Federally Recognized)

    • Federal Governments

      • Eligible Agencies of the Federal Government

      • U.S. Territory or Possession


  • Federal Governments

    • Eligible Agencies of the Federal Government

    • U.S. Territory or Possession

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